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KICCOLATE™ (Croscarmellose Sodium)
KICCOLATE™ is a water-insoluble superdisintegrant based on internally cross-linked carmellose sodium. As the exclusive global distributor for Nichirin Chemical Industries Co., Ltd., Asahi Kasei supplies two grades, ND-2HS and ND-200, to customers worldwide.
Grade Lineup
- ND-2HS
- ND-200
Function & Features
- Excellent Disintegration at Low Use Levels
- Low Sensitivity to pH & Viscosity
- Low Sensitivity to Hardness & Compression Force
- Consistent Long-Term Stability
Experimental
example
Disintegration of Tablets Containing 30% Ethenzamide
Dissolution of Tablets Containing 30% Ethenzamide
Dissolution of Tablets Containing 50% Sodium Salicylate
Images of Particles
- ND-2HS
Particle
Swollen State (Purified Water)
Swollen State (JP 1st Fluid (pH 1.2))
Swollen State (JP 2nd Fluid (pH 6.8))
General properties
| Grade | ND-2HS | ND-200 | |
|---|---|---|---|
|
Setting Volume (mL)* |
Purified Water |
23 | 15 |
|
JP 1st Fluid (pH1.2) |
17 | 13 | |
|
JP 2nd Fluid (pH6.8) |
22 | 13 | |
|
Particle size： > 75 μm (200 mesh) |
not more than 5.0% | ||
| Loose Bulk Density (g/cm3)* | 0.44 | 0.45 | |
| Tapped Density (g/cm3)* | 0.65 | 0.69 | |
| Water Absorption Capacity (g/g)* | 7.1 | 4.7 | |
| Angle of Repose (°) | 44 | 44 | |
*Sedimentation Volume: The volume was measured after immersing 1.5 g of powder in each test liquid for 4 hours.
*Loose Bulk Density: Measured using the double-cylinder method with loose filling.
*Tapped Density: Measured using the double-cylinder method after 100 taps.
*Water Absorption Capacity: Purified water was added from a burette to 1.0 g of powder until it became paste-like and water exuded on the surface. The total volume added was defined as the water absorption capacity.
Pharmacopoeia listings
JP : Croscarmellose Sodium
USP/NF : Croscarmellose Sodium
Ph. Eur. : Croscarmellose Sodium
Packaging information (Net Weight)
| Grade | |
|---|---|
| ND-2HS | Polyethlene bag in fiber drum (25 kg) |
| ND-200 | Polyethlene bag in fiber drum (25 kg) |