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Ceolus™ KG
Ceolus™ KG is a highly compactible MCC with fibrous particles.
It enables poorly compactible and/or high dose formulations. It solves tableting issues such as insufficient
hardness, sticking or capping.
Functional benefits
- Enables poorly compactible and/or high dose formulations
- Solves tableting issues
Insufficient hardness, sticking, capping, high friability - Enables unique and patient-friendly dosage forms
MUPS, ODT, multiple-layer tablets, multiple-API-combination tablets, small tablets, mini tablets - Enables low-pressure tableting
Applicable for pressure-sensitive API tablets and coated granules
Function & features
- High compactibility
- High oil absorption
- Fibrous particles
Map of Ceolus™ Compactibility vs. Flowability
* Comparison of tablet hardness, with the formulation of PH-101 = 1 set as the index point
Formulation: Acetaminophen/MCC = 70/30
Experimental
example
Tablet hardness
Tablet friability
* All tablets with PH-102 were broken during the friability test due to inherent capping tendency.
Metformin HCl/MCC/CCS/SiO2/Mg-St=70.8/26.1/2.1/0.5/0.5(%),
Direct compression (Rotary Press), Tablet size: 760 mg,φ12.0 mm - 16 R
Grade lineup
KG-1000
KG-802
Subject of comparison
PH-101
General properties
| Grade | Average Particle Size(μm) |
Bulk density (g/cm3) | Repose Angle(°） | Loss on Drying(%) |
Water absorption (%) |
Oil absorption (%) |
|
|---|---|---|---|---|---|---|---|
| Ceolus™ KG Highly compactible MCC with fibrous particles |
KG-1000 | 50 | 0.12 | 57 | 2.0-6.0 | 290 | 210 |
| KG-802 | 50 | 0.21 | 49 | 2.0-6.0 | 230 | 160 | |
| Ceolus™ PH Standard grade with high quality |
PH-101 | 50 | 0.29 | 45 | 2.0-6.0 | 200 | 120 |
| PH-102 | 90 | 0.30 | 42 | 2.0-6.0 | 200 | 140 |
All values presented here are solely for the purpose of basic reference and should not be regarded as specifications.
Pharmacopoeia listings
JP : Microcrystalline Cellulose
USP/NF : Microcrystalline Cellulose
Ph. Eur. : CELLULOSE, MICROCRYSTALLINE
Packaging information
| Grade | Net weight | Packaging type |
|---|---|---|
| KG-1000 | 10 kg | Polyethylene bag in kraft paper bag |
| KG-802 | 15 kg | Polyethylene bag in kraft paper bag |
Formulation examples
* You can download PDF files after log in Member page.
Capping Prevention - High dose tablets
Ceolus™ KG
Formulations with poorly compactible or high-dose APIs have the higher possibility of capping. Conventional MCC grades have insufficient compactibility, and the inherent capping can result in high tablet friability. By using a highly compactible MCC, the tablet's binding ability is increased and capping can be suppressed.
Challenges
Key words
Improvement of tablet friability - High-dose tablets
Ceolus™ KG
High-dose formulations by direct compression limits space for excipients, and tableting issues such as capping, sticking and tablet friability are predicted. These issues could be solved with a small amount of a highly compactible MCC.
Challenges
Key words
Improvement of tablet friability for film coating
Ceolus™ KG
Regarding tablet film coating, the airborne powder inside the coating machine can penetrate the film layer, potentially affecting tablet dissolution. By using a highly compactible MCC, the tablet's binding ability is increased and tablet friability is reduced, leading to reduced impact on the film layer and tablet dissolution.
Challenges
Key words