Ceolus™ UF is a porous MCC with balance of compactibility and flowability.
It enables a balance of tablet hardness and tablet disintegration. It solves tableting issues such as insufficient API
content uniformity or over-lubrication.
Map of Ceolus™ Compactibility vs. Flowability
* Comparison of tablet hardness, with the formulation of PH-101 = 1 set as the index point
Formulation: Acetaminophen/MCC = 70/30
Tablet weight variance
Ascorbic acid/MCC/Spray dried lactose/CCS/Mg-St=75/20/3/2/1.5 (extra) (%),
Direct compression (Rotary press), Tablet size: 180 mg, φ8 mm -12 R
Subject of comparison
|Bulk density (g/cm3)||Repose Angle(°）||Loss on
Porous MCC with balance of compactibility and flowability
Standard grade with high quality
All values presented here are solely for the purpose of basic reference and should not be regarded as specifications.
JP : Microcrystalline Cellulose
USP/NF : Microcrystalline Cellulose
Ph. Eur. : CELLULOSE, MICROCRYSTALLINE
|Grade||Net weight||Packaging type|
|UF-702||15 kg||Polyethylene bag in kraft paper bag|
|UF-711||15 kg||Polyethylene bag in kraft paper bag|
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In high shear granulation, the granulation time affects the compactibility, disintegration and dissolution properties of granules. In particular, longer granulation time tends to deteriorate the compactibility, disintegration or dissolution properties. Ceolus™ UF grade is a round and porous MCC and its high swellability can reduce adverse effects of high shear granulation on tablet hardness, disintegration and dissolution.
API segregation is one of typical challenges in direct compression of low dose API formulations. A porous MCC particle forms an ordered mixture by API adhesion on its surface. The ordered mixture mitigates API segregation risk and provides better API content uniformity compared to conventional MCCs.
In direct compression of formulation with poorly flowable APIs, increasing the tableting speed tends to cause tablet weight variance. A high flowable MCC may improve flowability of mixed powder, prevent tablet weight variance, and increase tableting speed.