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Ceolus™ UF
Ceolus™ UF is a porous MCC with balance of compactibility and flowability.
It enables a balance of tablet hardness and tablet disintegration. It solves tableting issues such as insufficient API
content uniformity or over-lubrication.
Functional benefits
- Enables a balance of tablet hardness and tablet disintegration
- Solves tableting issues (Insufficient API content uniformity, over-lubrication)
- Enables poorly flowable and/or low dose formulations
- Enables high speed tableting
Function & features
- Balance of compactibility and flowability
- High swellability
- Low sensitivity to lubricant
- Porous particles
Map of Ceolus™ Compactibility vs. Flowability
* Comparison of tablet hardness, with the formulation of PH-101 = 1 set as the index point
Formulation: Acetaminophen/MCC = 70/30
Experimental
example
Tablet hardness
Tablet weight variance
Ascorbic acid/MCC/Spray dried lactose/CCS/Mg-St=75/20/3/2/1.5 (extra) (%),
Direct compression (Rotary press), Tablet size: 180 mg, φ8 mm -12 R
Grade lineup
UF-702
UF-711
Subject of comparison
PH-101
General properties
| Grade | Average Particle Size(μm) |
Bulk density (g/cm3) | Repose Angle(°） | Loss on Drying(%) |
Water absorption (%) |
Oil absorption (%) |
|
|---|---|---|---|---|---|---|---|
| Ceolus™ UF Porous MCC with balance of compactibility and flowability |
UF-702 | 90 | 0.29 | 34 | 2.0-6.0 | 240 | 160 |
| UF-711 | 50 | 0.22 | 42 | 2.0-6.0 | 240 | 150 | |
| Ceolus™ PH Standard grade with high quality |
PH-101 | 50 | 0.29 | 45 | 2.0-6.0 | 200 | 120 |
| PH-102 | 90 | 0.30 | 42 | 2.0-6.0 | 200 | 140 |
All values presented here are solely for the purpose of basic reference and should not be regarded as specifications.
Pharmacopoeia listings
JP : Microcrystalline Cellulose
USP/NF : Microcrystalline Cellulose
Ph. Eur. : CELLULOSE, MICROCRYSTALLINE
Packaging information
| Grade | Net weight | Packaging type |
|---|---|---|
| UF-702 | 15 kg | Polyethylene bag in kraft paper bag |
| UF-711 | 15 kg | Polyethylene bag in kraft paper bag |
Formulation examples
* You can download PDF files after log in Member page.
Balance of tablet hardness and tablet disintegration - High shear granulation
Ceolus™ UF
In high shear granulation, the granulation time affects the compactibility, disintegration and dissolution properties of granules. In particular, longer granulation time tends to deteriorate the compactibility, disintegration or dissolution properties. Ceolus™ UF grade is a round and porous MCC and its high swellability can reduce adverse effects of high shear granulation on tablet hardness, disintegration and dissolution.
Challenges
Key words
Improvement of API content uniformity
Ceolus™ UF
API segregation is one of typical challenges in direct compression of low dose API formulations. A porous MCC particle forms an ordered mixture by API adhesion on its surface. The ordered mixture mitigates API segregation risk and provides better API content uniformity compared to conventional MCCs.
Challenges
Key words
Improvement of tablet weight variance under high speed tableting
Ceolus™ UF
In direct compression of formulation with poorly flowable APIs, increasing the tableting speed tends to cause tablet weight variance. A high flowable MCC may improve flowability of mixed powder, prevent tablet weight variance, and increase tableting speed.
Challenges
Key words