Control Tablet Disintegration and
Dissolution with MCC Ceolus™
When developing generic drugs, adjusting the MCC grade helps achieve disintegration and dissolution profiles similar to the original drug. Ceolus™ KG slows these processes due to its unique particle morphology, while Ceolus™ UF accelerates them.
Comparing Ceolus™ Grades: Disintegration and Dissolution Performance
Our comparison of Ceolus™ KG, UF, and PH grades reveals how different MCC types affect tablet disintegration and dissolution rates.
Formulation Example
Ceolus™ UF tends to accelerate tablet disintegration and dissolution compared to Ceolus™ PH-101. Ceolus™ KG tends to slow tablet disintegration and dissolution compared to Ceolus™ PH-101.
Formulation
Procedure
Solutions Made Possible by Asahi Kasei MCC Products
Capping Prevention
-
- Problem
- Increased compression force resulting from poor API compatibility and high API dosage increases the risk of capping.
-
- Solution
- Highly compactible MCC reduces the risk of capping even at high compression forces by strengthening the tablet bondings.
-
- Product
-
Ceolus™ KG
Balance of Tablet Hardness and Disintegration
-
- Problem
- In high-shear granulation, achieving the target tablet hardness and disintegration is challenging because granulation conditions affect these parameters.
-
- Solution
- Porous MCC with high swellability helps minimize the impact on tablet hardness and disintegration/dissolution during granulation.
-
- Product
-
Ceolus™ UF
Low Levels of Nitrite Content in Ceolus™ MCC
Starting in July 2024, Asahi Kasei Ceolus™ microcrystalline cellulose (MCC) guarantees nitrite levels of 0.1 ppm (μg/g) or less across our current primary grades, with test results included in every Certificate of Analysis (COA).
| Grade | Number of Batches Tested | Number of Batches Below LOD (0.008 μg/g) |
Maximum Nitrite Observed (μg/g) | |
|---|---|---|---|---|
| Ceolus™ KG Highly compactible MCC with fibrous particles |
KG-1000 | 14 | 12 | 0.011 |
| KG-802 | 23 | 20 | 0.014 | |
| Ceolus™ UF Porous MCC with balance of compactibility and flowability |
UF-702 | 25 | 23 | 0.010 |
| UF-711 | 22 | 21 | 0.010 | |
| Ceolus™ PH High-quality standard grade |
PH-101 | 33 | 14 | 0.034 |
| PH-102 | 39 | 15 | 0.026 | |
| PH-200 | 8 | 4 | 0.022 | |
| PH-301 | 9 | 9 | < 0.008 | |
| PH-302 | 7 | 6 | 0.010 | |
Results derived from testing done internally at Asahi Kasei
Ceolus™ MCC Grade Lineup
| Grade | Average Particle Size(μm) | Bulk density(g/cm3) | Repose Angle(°) | Loss on Drying(%) | Water absorption(%) | Oil absorption(%) | |
|---|---|---|---|---|---|---|---|
| Ceolus™ KG Highly compactible MCC with fibrous particles |
KG-1000 | 50 | 0.12 | 57 | 2.0-6.0 | 290 | 210 |
| KG-802 | 50 | 0.21 | 49 | 2.0-6.0 | 230 | 160 | |
| Ceolus™ UF Porous MCC with balance of compactibility and flowability |
UF-702 | 90 | 0.29 | 34 | 2.0-6.0 | 240 | 160 |
| UF-711 | 50 | 0.22 | 42 | 2.0-6.0 | 240 | 150 | |
| Ceolus™ PH High-quality standard grade |
PH-101 | 50 | 0.29 | 45 | 2.0-6.0 | 200 | 120 |
| PH-102 | 90 | 0.30 | 42 | 2.0-6.0 | 200 | 140 | |
| PH-200 | 170 | 0.35 | 36 | 2.0-6.0 | 200 | 140 | |
| PH-301 | 50 | 0.41 | 41 | 2.0-6.0 | 150 | 90 | |
| PH-302 | 90 | 0.43 | 38 | 2.0-6.0 | 170 | 100 | |
| PH-F20JP | 20 | 0.23 | ≦60 | ≦7.0 | 220 | 100 | |
Note: Values shown are for reference only and are not product specifications.
Map of Ceolus™ Compactibility vs. Flowability
Asahi Kasei Healthcare Materials Division
The Asahi Kasei Healthcare Materials Division provides MCCs for oral solid dosage forms in pharmaceuticals and nutraceuticals.
We have supplied MCC products to the Japanese pharmaceutical market for over 50 years, achieving a majority market share due to their reliability.
A significant advantage of our MCC products is their ability to support challenging and innovative formulations for pharmaceuticals and nutraceuticals that our customers are bringing to market.
Experience the Ceolus™ Advantage Today
Discover the superior quality of Ceolus™ MCC and enhance your pharmaceutical formulations with our premium materials. Request your free sample today to take the first step towards creating safer, more reliable products.