Capping Prevention Solutions
with Ceolus™ High-Perfomance MCC
Minimize Capping Risks in High-Dose and Poorly Compactible Formulations
Why Choose Ceolus™ MCC for Capping Prevention?
- Enhances Tablet Integrity: Helps reduce capping and improve tablet hardness without the need for excessive compression force.
- Optimized Compactibility: Offers superior binding properties to support robust tablet formation.
- Proven Performance: Effectively used in a range of challenging formulations.
1. Capping Prevention – High-Dose Tablets
Formulations containing poorly compactible or high-dose APIs are more prone to capping. Conventional MCC grades may not provide the necessary compactibility, which can result in weaker tablets and higher friability.
Solution: Ceolus™ KG
Highly compactible Ceolus™ KG improves the tablet's binding properties, reducing the risk of capping and helping to ensure stronger tablets.
Formulation Example
Ceolus™ KG achieved higher tablet hardness and lower tablet friability than other materials.
All tablets without Ceolus™ KG were broken during the friability test due to inherent capping tendency.
Formulation
Procedure
2. Capping Prevention – Extra Addition of MCC
When tableting poorly compactible granules, achieving the desired tablet hardness often requires high compression forces, increasing the risk of capping.
Solution: Extra Addition of Ceolus™ KG-1000
Adding a small amount of highly compactible Ceolus™ KG-1000 significantly enhances binding ability, allowing for effective capping prevention at lower compression forces.
Formulation Example
Ceolus™ KG-1000 achieved the highest tablet hardness and the lowest tablet friability.
Other formulations showed high tablet friability at 12 kN due to capping.
Formulation
Procedure
Experience Reliable Tableting with Ceolus™ MCC
Achieve consistent tablet quality while reducing capping risks. Contact us today to discover how Ceolus™ MCC can enhance your formulations.
Low Levels of Nitrite Content in Ceolus™ MCC
Starting in July 2024, Asahi Kasei Ceolus™ microcrystalline cellulose (MCC) guarantees nitrite levels of 0.1 ppm (μg/g) or less across our current primary grades, with test results included in every Certificate of Analysis (COA).
| Grade | Number of Batches Tested | Number of Batches with less than LOD (0.008 ppm) |
Nitrite max observed (ppm) | |
|---|---|---|---|---|
| Ceolus™ KG Highly compactible MCC with fibrous particles |
KG-1000 | 20 | 18 | 0.011 |
| KG-802 | 30 | 27 | 0.014 | |
| Ceolus™ UF Porous MCC with balance of compactibility and flowability |
UF-702 | 32 | 30 | 0.010 |
| UF-711 | 26 | 25 | 0.010 | |
| Ceolus™ PH High-quality standard grade |
PH-101 | 39 | 15 | 0.034 |
| PH-102 | 52 | 21 | 0.026 | |
| PH-200 | 13 | 5 | 0.027 | |
| PH-301 | 12 | 8 | 0.027 | |
| PH-302 | 10 | 8 | 0.016 | |
Batches in the 1st Manufacturing Site (Nobeoka)
Results derived from testing done internally at Asahi Kasei
High Performance MCC
Ceolus™ KG
Ceolus™ KG is a highly compactible MCC with fibrous particles, ideal for poorly compactible and high-dose formulations. It addresses tableting issues like insufficient hardness, sticking, and capping.
Functional benefits
- Enables poorly compactible and high-dose formulations
- Resolves tableting issues: insufficient hardness, sticking, capping, high friability
- Supports unique and patient-friendly dosage forms: MUPS, ODT, multi-layer tablets, multi-API combination tablets, small tablets, mini tablets
- Allows low-pressure tableting: suitable for pressure-sensitive API tablets and coated granules
Ceolus™ UF
Ceolus™ UF is a porous MCC that balances compactibility and flowability, ensuring a good balance of tablet hardness and disintegration. It addresses tableting issues like insufficient API content uniformity and over-lubrication.
Functional benefits
- Balances tablet hardness and disintegration
- Resolves tableting issues: insufficient API content uniformity, over-lubrication
- Supports poorly flowable and low-dose formulations
- Enables high-speed tableting
Ceolus™ MCC Grade Lineup
| Grade | Average particle size (μm) | Bulk density (g/cm3) | Repose angle (°) | Loss on drying (%) | Water absorption (%) | Oil absorption (%) | |
|---|---|---|---|---|---|---|---|
| Ceolus™ KG Highly compactible MCC with fibrous particles |
KG-1000 | 50 | 0.12 | 57 | 2.0-6.0 | 290 | 210 |
| KG-802 | 50 | 0.21 | 49 | 2.0-6.0 | 230 | 160 | |
| Ceolus™ UF Porous MCC with balance of compactibility and flowability |
UF-702 | 90 | 0.29 | 34 | 2.0-6.0 | 240 | 160 |
| UF-711 | 50 | 0.22 | 42 | 2.0-6.0 | 240 | 150 | |
| Ceolus™ PH High-quality standard grade |
PH-101 | 50 | 0.29 | 45 | 2.0-6.0 | 200 | 120 |
| PH-102 | 90 | 0.30 | 42 | 2.0-6.0 | 200 | 140 | |
| PH-200 | 170 | 0.35 | 36 | 2.0-6.0 | 200 | 140 | |
| PH-301 | 50 | 0.41 | 41 | 2.0-6.0 | 150 | 90 | |
| PH-302 | 90 | 0.43 | 38 | 2.0-6.0 | 170 | 100 | |
| PH-F20JP | 20 | 0.23 | ≦60 | ≦7.0 | 220 | 100 | |
Note: Values shown are for reference only and are not product specifications.
Map of Ceolus™ Compactibility vs. Flowability
Asahi Kasei Healthcare Materials Division
The Asahi Kasei Healthcare Materials Division provides MCCs for oral solid dosage forms in pharmaceuticals and nutraceuticals.
We have supplied MCC products to the Japanese pharmaceutical market for over 50 years, achieving a majority market share due to their reliability.
A significant advantage of our MCC products is their ability to support challenging and innovative formulations for pharmaceuticals and nutraceuticals that our customers are bringing to market.
Experience the Ceolus™ Advantage Today
Discover the superior quality of Ceolus™ MCC and enhance your pharmaceutical formulations with our premium materials. Request your free sample today to take the first step towards creating safer, more reliable products.