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CELPHERE® is a 100% MCC spherical seed core, used in the manufacturing of granules with sustained-release, taste-masked, and other special properties.
USP / NF
Microcrystalline Cellulose |
Ph.Eur.
Microcrystalline Cellulose |
SCP : JP
Microcrystalline Cellulose |
CP : JPE
Microcrystalline Cellulose Spheres |
Typical properties
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SCP-100 |
CP-102 |
CP-203 |
CP-305 |
CP-507 |
CP-708 |
| Particle size range (μm) |
75 - 212 |
106 - 212 |
150 - 300 |
300 - 500 |
500 - 710 |
710 - 850 |
| Sphericity |
1.2 |
1.2 |
1.1 |
1.1 |
1.2 |
1.2 |
| Bulk density (g/cm3) |
0.66 |
0.83 |
0.87 |
0.91 |
0.93 |
0.93 |
| Friability (%) |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
0.0 |
| Water absorption (%) |
130 |
100 |
100 |
110 |
70 |
65 |
Note: All values are presented only for the purpose of basic reference and not as specifications.
Features and functions
| •High mechanical strength |
•Low reactivity |
•High sphericity |
| •Fine and uniform particle cize |
•Optimum water absorption |
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Reduction of particle agglomeration
With CELPHERE®, agglomeration during coating process is minimal. CELPHERE® makes it easy to manufacture coating granules and has distinct advantages over sugar spheres.
| Formulation |
| Granulating machine |
CF-360 |
| Seed cores |
CELPHERE® CP-305 or sugar spheres |
| Model drug |
Powdered sucrose (20% of core wt.) |
| Binder solution |
3% HPC-L aqueous solution |
| Agglomeration vs. spray rate |
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*Granules in agglomerales of 500 μm larger, as percent of all granules.
Package
Polyethylene bag in cardboard box
20kg net weight
Further technical data and information are available in the member's site.
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